CORDIS Project
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This project focuses on understanding the role of infrequently mutated genes in colorectal cancer initiation. By using advanced genetic techniques in organoid models, it aims to clarify the contributions of these mutations to tumorigenesis and inform cancer therapy.
Cancer genome sequencing has led to a paradigm shift in our understanding of oncogenesis.
It has identified thousands of genetic alterations that segregate into two groups, a small number of frequently mutated genes and a much larger number of infrequently mutated genes.
The causative role of frequently mutated genes is often clear and are the focus of concerted therapeutic development efforts.
The role of those infrequently mutated is often unclear and can be difficult to separate from ‘mutatio…
THE UNIVERSITY OF EDINBURGH
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