CORDIS Project
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The CoMAnD project investigates the interplay between the Epstein-Barr virus, the MYC oncogene, and the tumor microenvironment in diffuse large B-cell lymphoma. By utilizing advanced imaging techniques and new DLBCL models, the project aims to uncover mechanisms that enable these tumors to evade cell death and resist c…
Diffuse large B-cell lymphoma (DLBCL) accounts for over one-third of lymphomas and is fatal in up to 40% of cases.
Particularly poor survival is associated with DLBCL subtypes that over-express the oncogene MYC and contain the cancer-causing Epstein-Barr virus (EBV).
These tumours frequently resist apoptosis, with a poorer response to chemotherapy.
Recent evidence has strongly implicated a role for the tumour microenvironment (TME) in cancer progression; however, the relationship between EBV, MY…
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