CORDIS Project
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This project examines how different conditioning regimens affect the behavior of transferred T cells in lymphopenic hosts, with a focus on improving immunotherapy strategies for cancer treatment. It studies T cell proliferation and function in various environments.
The ability of adoptively-transferred T cells to mediate an immune response is modulated by the host environment.
It has previously been shown that donor T cells proliferate and acquire memory-like characteristics when injected into lymphopenic hosts while in hosts with a « full » T cell compartment, they remain naïve and do not acquire effector function.
As it is important to optimize the persistence and responsiveness of transferred T cells for immunotherapy strategies, we assessed whether T c…
CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE CNRS
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