CORDIS Project
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This project investigates the dynamics of protein conformations using Nuclear Magnetic Resonance spectroscopy. It aims to develop new methods to measure protein motions in solid states, enhancing understanding of their biological functions and roles in diseases.
Conformational dynamics are intimately linked to the biological activity of proteins, thereby regulating the essential processes of life.
In particular protein motion plays an essential role in catalysis, allowing conformational rearrangements to align key catalytic amino acids and in ligand binding allowing the entry of co-factors into areas that would otherwise be inaccessible.
Mobility also plays a major role in the thermodynamic stability of functional states; in molecular recognition proces…
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