CORDIS Project
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This project investigates the interaction between the oncoprotein MYC and Aurora kinase A, aiming to develop small molecules that can indirectly target MYC for cancer treatment. It employs molecular dynamics simulations to understand this interaction and improve drug design.
In recent years, remarkable advances in cancer research and treatment have been made.
Still, little progress is observed in the treatment of specific solid tumours, e.g. hepatocellular carcinoma.
The oncoprotein MYC is frequently involved in the genesis and maintenance of human solid tumours and therefore represents a highly promising drug target.
Unfortunately, as MYC does not withhold any potential binding cavities for druglike small-molecules, it has been long considered as an undruggable pro…
EBERHARD KARLS UNIVERSITAET TUEBINGEN
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