CORDIS Project
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This project investigates how the condensin complex interacts with chromatin fibers to extrude DNA loops, a process crucial for chromosome segregation. By examining the effects of nucleosome arrays and linker histone H1, the research aims to clarify condensin's role in managing DNA organization within cells, which is v…
The three-dimensional organization of chromosomal DNA is essential for critical genomic functions, including chromosome segregation, gene expression, and DNA damage repair.
Structural Maintenance of Chromosomes (SMC) complexes, such as cohesin, the Smc5/6 complex, and condensin, are integral to preserving chromosomal architecture and supporting these vital processes.
Condensin folds DNA into mitotic chromosomes through DNA loop extrusion, a process critical for proper chromosome segregation.
Rec…
JULIUS-MAXIMILIANS-UNIVERSITAT WURZBURG
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