CORDIS Project
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This project investigates the role of beta-arrestin in the regulation of endocannabinoid production and G-protein-independent signaling in cannabinoid receptors. It employs both in vitro molecular biology techniques and in vivo studies using genetically modified mice to enhance understanding of the endocannabinoid syst…
The endocannabinoid system is composed of endocannabinoids, such as anandamide and 2-arachidonoylglycerol (2-AG), their metabolizing enzymes and cannabinoid receptors.
To date, two cannabinoid receptors have been identified by molecular cloning, the CB1 and CB2 receptors.
The endocannabinoid system has been implicated in a number of physiological functions, and pharmacological manipulation of this system is a promising therapeutic target in a large number of different diseases and conditions, in…
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