CORDIS Project
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This project investigates the role of retinoic X receptors in the differentiation of hematopoietic stem cells and the formation of osteoclasts, which are critical for bone health. Using a mouse model, the research aims to clarify how these receptors influence blood cell development and bone maintenance, potentially inf…
Hematopoietic stem cells (HSCs) yield blood precursors devoted to unilineage differentiation and production of mature blood cells, including red blood cells, megakaryocytes, lymphocytes and myeloid cells.
Precursors of the myeloid lineage differentiate into monocytes and granulocytes but at given stages of their maturity they can be also sources of multinucleated osteoclasts.
Consequently, any altered myelopoiesis can be directly linked to deficiencies in osteclastogenesis and impaired bone home…
CENTRO NACIONAL DE INVESTIGACIONES CARDIOVASCULARES CARLOS III (F.S.P.)
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