CORDIS Project
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This project investigates the role of the WWOX gene in breast cancer. By creating a mouse model that lacks WWOX in mammary cells, the study aims to understand how this gene suppresses tumor growth and its potential as a therapeutic target for breast cancer treatment.
Chromosomal and genomic abnormalities affecting chromosome 16q have frequently been reported in cytogenetic and allelotypic studies of various epithelial tumors, including breast cancer.
The WWOX gene has been recently cloned and described. WWOX spans a genomic region of more than 1 MB located in ch. 16q23.1.
This specific region is the most frequent target for LOH affecting 16q in breast cancer.
The critical role of WWOX in breast cancer was recently highlighted by the suppression of tumor grow…
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