CORDIS Project
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This project investigates how developmental processes in mouse embryos are coordinated in space and time, particularly during the peri-implantation phase. By using advanced imaging and culture techniques, it aims to understand the mechanisms behind size regulation and the interactions between embryos and uterine tissue…
Self-organisation is a defining feature of living systems and entails complex interplay between multiple parameters across various spatio-temporal scales.
Using pre-implantation mouse embryos as a model system, our studies revealed a principle of regulative development, in which feedback between cell fate, polarity and mechanics ensures robust control of embryo size, shape and pattern.
However, as embryos undergo implantation, this self-organisation mechanism has to be integrated in its spatio-t…
KONINKLIJKE NEDERLANDSE AKADEMIE VAN WETENSCHAPPEN - KNAW
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