CORDIS Project
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This project investigates the role of the Smc5-Smc6 complex in DNA replication and repair, focusing on its function in stabilizing and restarting replication forks that encounter damage. By developing molecular techniques, the project aims to identify key factors involved in maintaining genome integrity, which could le…
DNA replication represents a dangerous moment in the life of the cell as endogenous and exogenous events challenge genome integrity by interfering with the progression, stability and restart of the replication fork.
Failure to protect stalled forks or to process the replication fork appropriately contribute to the pathological mechanisms giving rise to cancer, therefore an understanding of the intricate mechanisms that ensure fork integrity can provide targets for new chemotherapeutic assays.
Sm…
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