CORDIS Project
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This project investigates how patterning and growth are coordinated in developing organs, specifically in the vertebrate nervous system. It focuses on the role of the Sonic hedgehog morphogen in regulating neuronal progenitor proliferation and differentiation, aiming to uncover fundamental principles of tissue developm…
Developing organs are patterned as they grow, but it is poorly understood how patterning and growth are coordinated to produce tissues of correct final proportions.
In the vertebrate nervous system, neuronal type specification occurs in parallel with progenitor proliferation and differentiation.
In the ventral neural tube, a Sonic hedgehog (Shh) morphogen gradient organizes the pattern of neuronal progenitors, and also influences their proliferation.
How these two processes are coordinated and w…
MEDICAL RESEARCH COUNCIL
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