CORDIS Project
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This project investigates the regenerative capabilities of the spiny mouse's spinal cord, aiming to uncover the biological mechanisms behind its ability to heal. It will compare these mechanisms with those in non-regenerative mammals to identify pathways that could enable spinal cord regeneration.
It is widely documented that the adult mammalian central nervous system (CNS) does not regenerate.
This failure results from the inhibitory scar environment and the decline of developmental growth programs.
Overturning this dogma, the PI recently demonstrated that the spiny mouse (Acomys cahirinus) regenerates spontaneously the spinal cord, with robust functional recovery.
Her current preliminary data support that an early switch occurs in the injured Acomys spinal cord, allowing scar reversion…
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