CORDIS Project
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This project investigates the role of metabolic enzymes in regulating gene expression through their interactions with mRNA. By identifying specific enzymes and their target mRNAs, it aims to uncover new mechanisms of post-transcriptional control in cellular regulation.
The role of metabolic enzymes in the post-transcriptional control of gene expression is barely explored, with only a few cases deeply studied so far, such as aconitase 1 in iron metabolism or GAIT complex control of pro-inflammatory genes.
Here, we propose to identify metabolic enzymes that interact specifically with mRNA by unbiased proteomic and transcriptomic approaches and to investigate their potential roles as gene expression regulators.
Metabolic enzymes able to bind mRNAs will be identif…
EUROPEAN MOLECULAR BIOLOGY LABORATORY
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