CORDIS Project
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This project aims to develop a new Hi-C method to visualize the structure of replicating chromosomes, enhancing our understanding of DNA replication and its implications for cancer. The goal is to analyze chromosomal interactions during DNA replication to prevent defects.
DNA replication initiation is strictly regulated to ensure complete genome duplication.
In eukaryotes, temporal control of origin firing across chromosomes establishes replication timing domains.
Failures in the timing of replication initiation across chromosomes is implicated in DNA replication stress, a hallmark of cancer, but the function of these temporally restricted replication domains is not understood.
As well as the duplication of DNA, S-phase involves the duplication of all chromosome…
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United States, Amherst
Type: University / higher education
Activity type: Higher or Secondary Education Establishments
SME: No
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