CORDIS Project
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This project investigates how large protein complexes are formed co-translationally by multiple ribosomes and cofactors. It employs advanced techniques to understand the coordination, folding, and assembly of nascent protein chains, providing insights into cellular processes and disease mechanisms.
Most proteins function within larger complexes.
How these intricate structures are correctly formed is poorly understood, yet critical to all cellular processes and pathological conditions.
Recent breakthroughs suggest that multi-protein complexes form co-translationally, by super-assemblies of multiple ribosomes and other cofactors that are coordinated in time and space.
This striking notion contrasts starkly with textbook models and is key to the possibilities and failures of complex formation…
RUPRECHT-KARLS-UNIVERSITAET HEIDELBERG
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Switzerland, Zuerich
Type: University / higher education
Activity type: Higher or Secondary Education Establishments
SME: No
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