CORDIS Project
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This project seeks to expand the capabilities of small molecules in chemical biology to induce various biochemical changes in cells. By developing new probes and techniques, it aims to enhance our understanding of cellular processes and therapeutic applications.
Chemical biology has made remarkable strides over recent decades, producing potent and selective inhibitors for many proteins, including essential drug targets.
Despite these achievements, however, inhibition has been the primary mode of perturbation (GPCRs notwithstanding), whereas many biological processes are controlled through a rich spectrum of biochemical perturbations.
What if a small molecule could activate an enzyme?
Install or remove a post-translational modification (PTM)?
Or control…
WEIZMANN INSTITUTE OF SCIENCE
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