CORDIS Project
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This project investigates the role of N6-methyladenosine (m6A) modifications on RNA, particularly during meiosis in yeast. It aims to uncover how these modifications regulate gene expression and influence cellular responses, contributing to our understanding of post-transcriptional regulation.
Over 100 types of distinct modifications are catalyzed on RNA molecules post-transcriptionally.
In an analogous manner to well-studied chemical modifications on proteins or DNA, modifications on RNA - and particularly on mRNA - harbor the exciting potential of regulating the complex and interlinked life cycle of these molecules.
The most abundant modification in mammalian and yeast mRNA is N6-methyladenosine (m6A).
We have pioneered approaches for mapping m6A in a transcriptome wide manner, and…
WEIZMANN INSTITUTE OF SCIENCE
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