CORDIS Project
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This project investigates the role of the SLX4 DNA repair complex in regulating inflammation associated with cancer. By studying SLX4-deficient models, it aims to uncover how this complex influences immune responses and cytokine production, potentially leading to new cancer treatment strategies.
Cancer related inflammation (CRI) is a well-established hallmark of cancer.
We recently demonstrated that the DNA damage repair SLX4 complex suppresses spontaneous and human immunodeficiency virus (HIV)-dependent pro-inflammatory cytokine production, revealing a role for this DNA repair complex in controlling innate immune responses.
Bi-allelic mutations in SLX4 are involved in the onset of Fanconi Anemia (FA), a syndrome characterized, besides heightened cancer susceptibility, by severe defects…
CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE CNRS
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