CORDIS Project
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This project aims to understand the biological significance of long noncoding RNAs (lncRNAs) by mapping their functional domains using a novel high-throughput technique called CRISPR-Locate. The goal is to link lncRNA sequences to their functions, which could have implications in medicine and biology.
A great surprise in the wake of the Human Genome Project has been the discovery of vast numbers of RNAs that do not encode proteins.
Alongside 19,000 protein-coding genes, our genome contains at least 20,000 long noncoding RNA (lncRNA) genes, but recent estimates push that number to 100,000.
Extensive annotation efforts are presently discovering lncRNAs far faster than their functions can be elucidated, and thus only <1% of lncRNAs have been experimentally characterised.
These discoveries have c…
UNIVERSITY COLLEGE DUBLIN, NATIONAL UNIVERSITY OF IRELAND, DUBLIN
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Switzerland, Bern
Type: University / higher education
Activity type: Higher or Secondary Education Establishments
SME: No
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