CORDIS Project
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This project investigates how chromosomal instability (CIN) affects tumor evolution and immune responses. By identifying genes linked to CIN and immune evasion using advanced genetic screening techniques, the research aims to enhance understanding of cancer development and inform future therapeutic strategies.
Chromosomal instability (CIN) and the resulting aneuploidies can fuel the dramatic karyotype changes characteristic of tumorigenesis, helping tumors to alter the expression of immune checkpoints and evolving phenotypes related to immune evasion or stimulation.
Anti-tumor immunity appears to be dependent on the type and origin of the tumor, while immune evasion has become an obstacle to designing effective anticancer therapeutics.
Understanding when CIN promotes or suppress anti-tumor immunity i…
UNIVERSITAIR MEDISCH CENTRUM GRONINGEN
ACADEMISCH ZIEKENHUIS GRONINGEN
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