CORDIS Project
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This project focuses on understanding somatic copy number alterations in cancer cells, which affect gene expression and tumor development. By using CRISPR technology, it aims to create chromosomal deletions and explore their impact on liver cancer biology and potential therapies.
In 1914 Theodor Boveri described abnormal chromosome counts in cancer cells and speculated that these alterations are the driving force of cancer.
Almost 100 years later it became clear that somatic copy number alterations (SCNAs) are one of the most striking characteristics of cancer genomes. SCNAs comprise deletions and amplifications of whole chromosome arms and therefore alter the expression patterns of several hundred genes simultaneously.
These alterations show defined patterns suggesting…
UNIVERSITATSKLINIKUM HEIDELBERG
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Germany, Heidelberg
Type: Research institute
Activity type: Research Organisations
SME: No
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