CORDIS Project
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This project investigates the role of chemokines in tumor-host interactions, focusing on the effects of specific chemokines and their receptors on cancer progression and immune response. By studying modified tumor models, the research aims to enhance understanding of tumor immunity and identify new cancer treatment str…
Current immunotherapeutic strategies to combat cancer are hampered by the ability of tumors to escape immunity necessitating new mechanistic insights into underlying molecular and cellular processes.
Through orchestrating complex cellular moves and determining the positioning of immune cells, chemokines govern both productive immune responses and their silencing.
Chemokines signal through classical G-protein coupled receptors (GPCRs) but also bind atypical receptors (ACRs). ACRs modulate chemoki…
THE UNIVERSITY OF BIRMINGHAM
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