CORDIS Project
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This project aims to develop a novel multi-culture model system using patient-derived organoids to study the interactions between high-grade serous ovarian carcinoma and its tumor microenvironment. By analyzing treatment responses at the single-cell level, it seeks to uncover mechanisms of chemotherapy resistance and i…
To improve the poor clinical outcomes in high-grade serous ovarian carcinoma (HGSC), we need to understand the cancer cell-tumour microenvironment (TME) dynamic interactions upon disease evolution and treatment.
In my proposed project, I will establish a unique TME-HGSC patient-derived organoid (PDO) multi-culture model system to identify and understand how the TME impacts treatment responses and how treatment resistance can be overcome.To generate multi-culture PDO preclinical models of HGSC fo…
KOBENHAVNS UNIVERSITET
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