CORDIS Project
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This project investigates the evolutionary history of endogenous retroviruses (ERVs) and their relationship with exogenous retroviruses (XRVs). By analyzing mammalian genomes, it aims to understand cross-species transmission and the factors influencing viral adaptations.
Endogenous retroviruses (ERVs) are DNA fragments found dispersed in a wide range of genomes, from invertebrates to mammals, that resemble members of the Retroviridae viral family (termed here exogenous retroviruses or XRVs).
Because XRV replication involves integration into the host chromosome, it is generally assumed that ERVs are the result of ancient XRV infections, which have passed into the germ-line of the host and expanded within it. ERVs are classified into three classes, while XRVs are…
THE CHANCELLOR, MASTERS AND SCHOLARS OF THE UNIVERSITY OF OXFORD
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