CORDIS Project
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CROSSBONE investigates the role of skeletal stem progenitor cells in bone healing and fibrosis, particularly in conditions like Neurofibromatosis type 1. The project aims to understand the initial regulatory mechanisms affecting cell differentiation and healing outcomes through advanced experimental techniques.
Bone fractures are common traumatic injuries and a significant global health challenge.
Successful healing depends on skeletal stem progenitor cells (SSPCs) producing cartilage and bone via a complex process.
New vessel and nerve formations in the bone microenvironment are also crucial to determine the healing outcome.
When disrupted, bone healing is impaired and fibrosis emerges, impacting patients’ life.
In current research on bone repair disorders, there is a lack of understanding of initial…
INSTITUT NATIONAL DE LA SANTE ET DE LA RECHERCHE MEDICALE
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