CORDIS Project
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This project investigates the role of mast cells in immune responses, particularly their secretory granules and associated organelles. By employing advanced microscopy techniques, it aims to uncover the mechanisms behind the release of these granules and their potential metabolic functions, contributing to new therapeu…
Mast cells (MCs) are tissue resident immune cells best known for their role in allergy.
However, as part of the adaptive and innate immune system they engage in various pathologies including cancer and neurodegeneration.
When MCs exert their immune response, special lysosome-related organelles, called secretory granules (SG), in which protective and proinflammatory mediators are prestored, undergo exocytosis.
The recent discovery that during this process also mitochondrial and endoplasmic reticu…
FREIE UNIVERSITAET BERLIN
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