CORDIS Project
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This project investigates how extracellular vesicles (EVs) facilitate communication between organs, focusing on liver-derived EVs. Using a transparent zebrafish model, it aims to map EV targets, analyze cargo delivery, and determine the function of these vesicles in health and disease.
To coordinate activities between different tissues, multicellular organisms critically rely on intercellular communication.
Whereas homeostatic signalling within organs is studied extensively, inter-organ crosstalk is only starting to be unravelled.
In recent years, Extracellular Vesicles (EVs) have emerged as central mediators of this pathway by shuttling specific bioactive cargo including proteins between cells.
These nano-sized lipid vesicles are released by virtually every cell type, are tra…
UNIVERSITEIT UTRECHT
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