CORDIS Project
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This project investigates the structure and function of type 4 secretion systems in Enterococcus bacteria, which are responsible for antibiotic resistance. By using advanced imaging techniques, it aims to reveal the molecular architecture of these systems to inform new antibiotic development.
Gram-positive (G+) bacteria, such as the Enterococcus species faecium and faecalis, cause around half of hospital-acquired infections.
These infections are increasingly antimicrobial-resistant (AMR), which presents a major challenge for tackling the global burden of disease. AMR arises from mutant genes, which can be inherited, and also spread between bacterial species by conjugation through type 4 secretion systems (T4SS), which are protein complex. T4SS are an attractive target for new antibio…
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