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The cryo-SECOM project aims to automate the cryo-electron tomography workflow, significantly improving sample preparation efficiency. This integrated system will enhance imaging precision and reduce costs, facilitating advanced research in structural biology.
Cryo-electron tomography (cryo-ET) is a powerful technique that can faithfully image the native cellular environment at nanometer resolution and enables the acquisition of 3D images of large and pleomorphic objects, such as cells and organelles, with unprecedented resolution.
The main problem in the current cryo tomography workflow is the multiple critical steps needed to make the sample suitable for analysis.
Current labs use a workflow that involves at least 22 steps, limiting the throughput t…
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