CORDIS Project
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This project develops a novel hybrid imaging technique to study the interactions between actin and actin-binding proteins within cells. By improving structural understanding, the research aims to shed light on cell migration, which is crucial for understanding cancer metastasis.
Cell motility is driven by a complex network of force-generating biological machinery.
The key component in this machinery is the dynamic network of filamentous actin (F-actin) and actin binding proteins (ABPs) which maintain and regulate the network.
However, structural information for many ABP-actin complexes, as well as their in situ spatial distribution remain elusive.
This is because ABPs cannot be easily studied in isolation, often exhibiting structural stability only when embedded in a co…
INSTITUTE OF SCIENCE AND TECHNOLOGY AUSTRIA
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