CORDIS Project
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This project focuses on understanding the molecular processes of protein synthesis in cells, particularly the integration of membrane proteins. Using advanced imaging techniques, it aims to provide insights into ribosome function and protein assembly.
Translation of the genetically encoded information into polypeptides, protein biosynthesis, is a central function executed by ribosomes in all cells.
In the case of membrane protein synthesis, integration into the membrane usually occurs co-translationally and requires a ribosome-associated translocon (SecYEG/Sec61).
This highly coordinated process is poorly understood, since high-resolution structural information is lacking.
Although single particle cryo-electron microscopy (cryo-EM) has given…
LUDWIG-MAXIMILIANS-UNIVERSITAET MUENCHEN
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