CORDIS Project
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This project focuses on the COP9 Signalosome, a complex involved in various cellular functions. It aims to characterize the interactions between this complex and ubiquitin ligases, which are crucial for regulating protein degradation and cellular processes.
The COP9 Signalosome (CSN) is an eight-subunit molecular machine conserved in eukaryotes.
Defects in CSN function are reported in human disorders and a CSN-related pathway recently emerged as a promising cancer drug target. CSN regulates embryonic development, DNA repair, cell cycle checkpoint progression and autophagy.
The remarkable pleiotropy of CSN is partially explained through its enzymatic activity towards Cullin-RING E3 ubiquitin ligases (CRLs), which are activated by neddylation and ina…
EIDGENOESSISCHE TECHNISCHE HOCHSCHULE ZUERICH
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