CORDIS Project
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This project investigates the regulation of cullin-RING ligases by the COP9 signalosome, focusing on the molecular mechanisms that maintain ligases in an inactive state. Using advanced structural biology techniques, it aims to enhance understanding of protein degradation pathways critical for cell function.
Specificity in the ubiquitin-proteasome system is largely conferred by ubiquitin E3 ligases (E3s).
Cullin-RING ligases (CRLs), constituting ~30% of all E3s in humans, mediate the ubiquitination of ~20% of the proteins degraded by the proteasome. CRLs are divided into seven families based on their cullin constituent.
Each cullin binds a RING domain protein, and a vast repertoire of adaptor/substrate receptor modules, collectively creating more than 200 distinct CRLs.
All CRLs are regulated by th…
FRIEDRICH MIESCHER INSTITUTE FOR BIOMEDICAL RESEARCH FONDATION
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