CORDIS Project
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This research focuses on choline transport in cells, particularly the choline transporter-like family. It aims to elucidate the molecular mechanisms behind choline uptake, which is crucial for various biological processes and has implications for diseases like cancer.
Choline is an essential nutrient necessary for the synthesis of the membrane lipids phosphatidylcholine and sphingomyelin that constitute over 50 % of the total lipid content in cellular membranes.
It is the precursor for key metabolites such as the neurotransmitter acetylcholine and the osmolyte and methyl donor betaine.
Transmembrane uptake of choline is the essential, but still enigmatic, first step in choline metabolism in the cell.
Three groups of solute carriers have been identified in the…
AARHUS UNIVERSITET
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