CORDIS Project
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The project focuses on developing new synthetic methods for creating chiral rigid polycyclic structures, which are important in drug design. It aims to address the challenges in enantioselective synthesis, particularly for complex molecular scaffolds.
Drug candidates should have a higher proportion of Csp3 over Csp2 and Csp and a greater number of stereogenic centers.
That is essentially the message of F.
Lovering et al. in their seminal article Escape from Flatland published in 2009 which induced a paradigm change in drug design.
The first recommendation (higher proportion of Csp3) has opened a new field of research over the last 15 years, in a quest aiming at the synthesis and functionalization of small rigid polycyclic (bridged or caged) m…
CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE CNRS
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