CORDIS Project
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CURE-HF is developing small-molecule inhibitors targeting a gene linked to heart failure and diabetes. This innovative approach aims to enhance glucose uptake in heart cells, potentially improving treatment outcomes for patients suffering from both conditions.
Heart failure (HF) affects over 64 million people worldwide and is a leading cause of hospitalization and premature death.
About 40% of HF patients also have type 2 diabetes, doubling mortality risk.
In HF, the stressed myocardium shifts toward glucose metabolism, but in diabetes cardiomyocytes fail to take up glucose and remain reliant on fatty acids, leaving the heart energy-starved.
Current HF therapies target neurohormonal pathways to reduce workload and slow progression but do not address t…
UNIVERSITAIR MEDISCH CENTRUM GRONINGEN
ACADEMISCH ZIEKENHUIS GRONINGEN
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