CORDIS Project
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This project studies the role of the gap junction protein connexin 43 in chronic renal failure, aiming to understand its involvement in inflammation and fibrosis. It explores potential treatments targeting this protein to halt the progression of kidney disease.
Chronic renal failure (CRF), one of the main causes of disability in western societies, is promoted by a variety of factors including hypertension, diabetes, ischemic, immunological and toxic injury.
These factors are linked by their common ability to promote chronic inflammation and fibrosis leading to decline of renal function.
Dialysis and transplantation are the only available options that allow survival of patients.
Arresting the progression of CRF is one of the major challenges of public h…
INSTITUT NATIONAL DE LA SANTE ET DE LA RECHERCHE MEDICALE
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