CORDIS Project
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The project explores the role of D-type cyclins in cell cycle regulation, particularly during the G1 phase. It examines how cyclin D1 influences transcription and RNA export in both normal nervous system development and cancer, using innovative genetic models and modern analytical techniques.
Cyclins play role in the cell division machinery and dictate the proceeding of cell cycle phases. D-type cyclins activity is required for progression through G1 phase, the critical step when cells steer the wheel to enter a new cycle of proliferation, to exit cell cycle and become quiescent or ultimately to differentiate.
Generation of mice nullizygous for each of the three D-cyclin genes revealed their physiological impact as well as protective effect against cancer.
Cyclin D1 is important duri…
CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE CNRS
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