CORDIS Project
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This project investigates nanoscale synthetic cylinders that interact with DNA, focusing on how their design affects cell cycle processes. By manipulating their binding modes, the project aims to enhance the understanding of their biological effects and optimize their design for specific applications in molecular biolo…
The scientific aim of this proposed project is to understand what features of nanoscale synthetic cylinders, and which biomolecular binding mode, give rise to the observed biological effects on the cell cycle and to probe the mechanism and temporal relationships of that action in more detail.
Our hypothesis is that the cylinder recognition of Y-shaped junctions, particularly replication forks, is a key feature of their action.
The new design strategies will create cylinders which deconvolute the…
THE UNIVERSITY OF BIRMINGHAM
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