CORDIS Project
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This project examines the effects of chemotherapy on the blood-forming system in young cancer survivors. It aims to understand clonal dynamics and mitochondrial dysfunction using advanced single-cell analysis techniques.
Chemotherapy can cause significant damage to healthy tissues, especially in the hematopoietic system.
As a result, cancer survivors may experience bone marrow damage manifested as cytopenias, which increase the risk of infections and bleeding.
Despite this, there has not been a thorough examination of these events, including the clonal dynamics of hematopoiesis after chemotherapy exposure, due to a lack of methodologies to perform lineage tracing in humans in vivo.
To address this, I will study…
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