CORDIS Project
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This project investigates the process of abscission, the final step of cell division, focusing on the role of the ESCRT-III complex in membrane fission. It employs both in vitro assays and an innovative in vivo setup to explore how membrane mechanics influence cytokinesis at molecular and cellular levels.
Abscission is the ultimate event of cytokinesis during which the intracellular bridge connecting two daughter cells is irreversibly cleaved.
Reports show that a complex called ESCRT-III is involved in plasma membrane fission during abscission.
The goal of this project is to understand how membrane mechanics can influence the fate of cytokinesis both at the molecular and at the cellular levels.First, I will address the mechanism of ESCRT-III mediated membrane fission by using in vitro assays mimi…
UNIVERSITE DE GENEVE
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