CORDIS Project
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This project focuses on the role of the midbody ring in cytokinesis and its impact on cell differentiation and tumor development. By studying the inheritance of this organelle in the model organism Caenorhabditis elegans, the research aims to uncover its significance in normal development and cancer.
There is ample evidence for important roles of cytokinesis in animal development besides ensuring faithful division of daughter cells.
However, these additional functions and their mechanistic basis are not well understood.
With the work proposed here we will elucidate roles of cytokinesis in differentiation and tumorigenesis.
We will focus on the function of the midbody ring (MR), a protein-dense organelle that forms at the site of abscission during cytokinesis.
This organelle forms only once d…
JOHANN WOLFGANG GOETHE-UNIVERSITAET FRANKFURT AM MAIN
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