CORDIS Project
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The project aims to understand how cell-autonomous immunity detects and responds to intracellular parasites like Toxoplasma gondii. It focuses on identifying the mechanisms of host cell necrosis and the associated inflammatory pathways to inform potential therapeutic strategies.
My goal is to understand how cell-autonomous immunity (CAI) can detect intracellular parasites such as Toxoplasma gondii in their membrane-bounded intracellular niches, how recognition induces necrosis of the host cell, and how host death signalling pathways contribute to inflammatory disorders.
Although adaptive immunity ultimately contributes to host survival, the initial response is controlled by innate mechanisms.
Mice rely primarily on IFNγ-induced CAI effectors virtually absent in humans,…
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