CORDIS Project
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This project investigates how post-transcriptional modifications, specifically cytosine-5 methylation in RNA, influence stem cell behavior and fate. By analyzing these mechanisms, the research aims to uncover their roles in maintaining stem cell populations and their implications for neurological disorders.
Stem cells differentiate into all mammalian tissues and organs during development, and remain present to maintain and replenish tissues throughout life.
Stem cells continuously maintain their population (self-renewal) while generating progeny (differentiation).
During self-renewal stem cells have to avoid cell cycle exit and differentiation; whereas during differentiation stem cells must evade uncontrolled proliferation.
Dissecting the regulatory pathways controlling the balance between these t…
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