CORDIS Project
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This project investigates the role of the AIM2 protein in the immune response to viral and bacterial infections, focusing on its ability to detect cytosolic DNA. By understanding AIM2's mechanisms, the research aims to enhance immunotherapy and address autoimmune diseases.
Host cytokines, chemokines and type I IFNs are critical effectors of the innate immune response to viral and bacterial pathogens.
Several classes of germ-line encoded pattern recognition receptors have been identified, which sense non-self nucleic acids and trigger these responses.
Recently NLRP-3, a member of the NOD-like receptor (NLR) family, has been shown to sense endogenous danger signals, environmental insults and the DNA viruses adenovirus and HSV.
Activation of NLRP-3 induces the format…
UNIVERSITATSKLINIKUM BONN
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