CORDIS Project
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The project aims to engineer second-generation cytokines that bind more effectively to the extracellular matrix in targeted tissues. This approach seeks to enhance the therapeutic efficacy of growth factors in regenerative medicine by improving their localization and functionality.
In physiological situations, the extracellular matrix (ECM) sequesters cytokines, localizes them, and modulates their signaling.
Thus, physiological signaling from cytokines occurs primarily when the cytokines are interacting with the ECM.
In therapeutic use of cytokines, however, this interaction and balance have not been respected; rather the growth factors are merely injected or applied as soluble molecules, perhaps in controlled release forms.
This has led to modest efficacy and substantial…
ECOLE POLYTECHNIQUE FEDERALE DE LAUSANNE
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