CORDIS Project
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This project investigates how telomeres, the protective ends of linear chromosomes in eukaryotes, are replicated and how their length influences cell division and aging. Using innovative techniques in yeast, it aims to uncover the mechanisms behind telomere shortening and its role in cellular senescence.
Linear chromosomes of eukaryotes end with telomeres that ensure their stability.
Because of the inability of semi-conservative DNA replication machinery to fully replicate DNA ends, telomeres require dedicated mechanisms to be duplicated and their length is eroded at each cell division.
For this reason, telomeres constitute molecular clocks that determine cell proliferation potential in eukaryotes.
Strikingly, we have shown recently that it is the shortest telomere in the cell that determines th…
CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE CNRS
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