CORDIS Project
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The DABAT project investigates the role of specific proteins, AIM2 and DNase1L3, in the development of chronic graft-versus-host disease by studying their effects on B cells in both human and mouse models. The goal is to identify molecular mechanisms that could lead to new treatments for this condition following stem c…
A recent paradigm shift is that B cells are pivotal in chronic graft-versus-host-disease (cGVHD), which is the most relevant cause of late non-relapse morbidity and mortality after allogeneic haematopoietic stem cell transplantation. DABAT’s project hypothesis is that 1) DNA-sensing by AIM2 supports cGVHD pathological B cells through autocrine regulations and that 2) their DNase1L3 expression modulates DNA-sensing by AIM2.
Doctor Sarantopoulos (Duke University, US, supervisor for the outgoing ph…
UNIVERSITE DE BORDEAUX
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United States, Durham Nc
Type: University / higher education
Activity type: Higher or Secondary Education Establishments
SME: No
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