CORDIS Project
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This research focuses on DNA damage and genome stability, particularly through the lens of nucleotide excision repair (NER). It aims to understand the relationship between DNA repair defects and aging, with implications for cancer prevention and treatment strategies.
We study DNA damage and genome stability and its impact on human health using nucleotide excision repair (NER) as paradigm.
Patients with NER defects present a perplexing clinical heterogeneity ranging from extreme cancer predisposition to dramatic neurodevelopmental deficits.
To elucidate the underlying mechanism we adopted an integral strategy from gene to patient and contributed to resolving the NER reaction in vitro and its dynamic organization in vivo, using molecular genetics, advanced lif…
ERASMUS UNIVERSITAIR MEDISCH CENTRUM ROTTERDAM
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